Payame Noor University Health Psychology 2322-1283 9 36 2021 03 19 Investigatinon the Effect of Coping Therapy on Immunological Biomarkers among Multiple Sclerosis Patients Investigatinon the Effect of Coping Therapy on Immunological Biomarkers among Multiple Sclerosis Patients 169 183 7579 10.30473/hpj.2021.54522.4903 FA Fahimeh Amini Ph.D Student of Psychology, Payame Noor University of Tehran. Alireza Aghayousefi Associate Professor, Depatment of Psychology, Payame Noor University of Tehran Ahmad Alipour Professor, Department of Psychology, Payame Noor University of Tehran. Valli Allah Farzad Associate Professor, Department of Psychology, Kharazmi University. Journal Article 2020 08 10 <strong>Objective: </strong>The use of stress coping methods in multiple sclerosis patients can lead to significant changes in the level of cognitive immune biomarkers. Therefore, the aim of this research was Investigatin on the Effect of Coping Therapy on Immunological Biomarkers among Multiple Sclerosis Patients. <strong>Method:</strong> The present research was quasi-experimental with pretest-posttest method with control group. The study population included all patients with multiple sclerosis support member with MS. S. Tehran province was in 1397, 30 patients with M. S. Among eligible and volunteer patients, they were selected and randomly assigned to two experimental and control groups. The experimental group received eight sessions of treatment as copping therapy, and the control group received the same number of routine care sessions. To measure of the hypothesis, human Immunological Biomarkers kits were used to measure and blood samples collected 3 times and psychologically intervention was coping therapy. <strong>Findings:</strong> The results showed pre-test and post-test and follow-up component of IL-6, IL-10, TNF-α, INF-gama, white blood cells, lymphocytes and a significant difference (05/0> P) and grades stage follow-up measures remained fairly stable and lasting effect of the intervention is still coping therapy. <strong>Conclusion:</strong> The course of coping therapy improves the Immunological Biomarkers in patients with multiple sclerosis. In addition, this approach reduces the effectiveness of the intervention, follow-up time after the test had no effect <strong>Objective: </strong>The use of stress coping methods in multiple sclerosis patients can lead to significant changes in the level of cognitive immune biomarkers. Therefore, the aim of this research was Investigatin on the Effect of Coping Therapy on Immunological Biomarkers among Multiple Sclerosis Patients. <strong>Method:</strong> The present research was quasi-experimental with pretest-posttest method with control group. The study population included all patients with multiple sclerosis support member with MS. S. Tehran province was in 1397, 30 patients with M. S. Among eligible and volunteer patients, they were selected and randomly assigned to two experimental and control groups. The experimental group received eight sessions of treatment as copping therapy, and the control group received the same number of routine care sessions. To measure of the hypothesis, human Immunological Biomarkers kits were used to measure and blood samples collected 3 times and psychologically intervention was coping therapy. <strong>Findings:</strong> The results showed pre-test and post-test and follow-up component of IL-6, IL-10, TNF-α, INF-gama, white blood cells, lymphocytes and a significant difference (05/0> P) and grades stage follow-up measures remained fairly stable and lasting effect of the intervention is still coping therapy. <strong>Conclusion:</strong> The course of coping therapy improves the Immunological Biomarkers in patients with multiple sclerosis. In addition, this approach reduces the effectiveness of the intervention, follow-up time after the test had no effect https://hpj.journals.pnu.ac.ir/article_7579_ed9d1e5433a399667c369ce9577f772d.pdf