Payame Noor University QUARTERLY JOURNAL OF HEALTH PSYCHOLOGY 2322-1283 9 34 2020 08 22 Effectiveness of Existential Based Spiritual Intervention on Quality of Life and Life Meaning in Patients with Multiple Sclerosis Effectiveness of Existential Based Spiritual Intervention on Quality of Life and Life Meaning in Patients with Multiple Sclerosis 95 120 6970 10.30473/hpj.2020.48635.4563 FA Zahra Abdekhodaie ّFamily Research Institute, Shahid Beheshti Univercity, Tehran, Iran Shahriar Shahidi Clinical and Health Psychology Department, Faculty of Education and Psychology, Shahid Beheshti University, Tehran, Iran. Mohammad Ali Mazaheri Clinical and Health Psychology Department, Faculty of Education and Psychology, Shahid Beheshti University, Tehran, Iran. Laily Panaghi Clinical and Health Psychology Department, Faculty of Education and Psychology, Shahid Beheshti University, Tehran, Iran. Vahid Nejati Clinical and Health Psychology Department, Faculty of Education and Psychology, Shahid Beheshti University, Tehran, Iran. Journal Article 2019 08 31 <strong>Objective: </strong>This study aimed to investigate the effectiveness of existential based spiritual intervention on quality of life and life meaning in patients with multiple sclerosis (MS). <strong>Method:</strong> Qualitative single case method with multiple baseline was applied. 5 patients were selected through purposive convenience sampling and were interviewed. Intervention was developed in 12 topics and applied weekly in two one-hour sessions. The process and mechanisms of changes were evaluated using the quality of life and life meaning scales. After obtaining of baseline in pretest stage, the participants were evaluated during six stages treatment process and two stages follow-up. The data were analyzed via visuals inspection, reliable change index (RCI) and improvement percentage strategies. <strong>Findings:</strong> The percentage of improvement was calculated in two scales and at three stages for five participants. The average improvement rate in the intervention stage was 114.32% for the Meaning-in-Life and 79.4% for Quality of Life, and in the follow-up stage it was obtained 185.5% for the Meaning-in-Life and 123.28% for Quality of Life. Intervention has positive and stable effect on Quality and Meaning of Life, but the subscales changed in different manner. <strong>Conclusion:</strong> Existential based spiritual intervention, which had affections on different level in meaning life, enhanced the patients’ quality of life in physical and psychological level. So this psychological intervention will be useful for MS patients. <strong>Objective: </strong>This study aimed to investigate the effectiveness of existential based spiritual intervention on quality of life and life meaning in patients with multiple sclerosis (MS). <strong>Method:</strong> Qualitative single case method with multiple baseline was applied. 5 patients were selected through purposive convenience sampling and were interviewed. Intervention was developed in 12 topics and applied weekly in two one-hour sessions. The process and mechanisms of changes were evaluated using the quality of life and life meaning scales. After obtaining of baseline in pretest stage, the participants were evaluated during six stages treatment process and two stages follow-up. The data were analyzed via visuals inspection, reliable change index (RCI) and improvement percentage strategies. <strong>Findings:</strong> The percentage of improvement was calculated in two scales and at three stages for five participants. The average improvement rate in the intervention stage was 114.32% for the Meaning-in-Life and 79.4% for Quality of Life, and in the follow-up stage it was obtained 185.5% for the Meaning-in-Life and 123.28% for Quality of Life. Intervention has positive and stable effect on Quality and Meaning of Life, but the subscales changed in different manner. <strong>Conclusion:</strong> Existential based spiritual intervention, which had affections on different level in meaning life, enhanced the patients’ quality of life in physical and psychological level. So this psychological intervention will be useful for MS patients. https://hpj.journals.pnu.ac.ir/article_6970_7d15e78790eef9061875201f3ade7653.pdf